abstract：:Aldosterone plays an important role in electrolyte and blood pressure homeostasis. Our studies have focused on the role of aldosterone in essential hypertension. We have shown that plasma aldosterone and ARR are heritable characteristics and that aldosterone concentrations in older subjects are inversely correlated wi...

journal_title：Molecular and cellular endocrinology

authors： Davies E,Mackenzie SM,Freel EM,Alvarez-Madrazo S,Fraser R,Connell JM

更新日期：2009-03-05 00:00:00

abstract：:The Cre-loxP system combined with gene targeting strategies has proven to be very useful for gene inactivation in specific tissues and/or cell types. To achieve adrenal cortex specific recombination in vivo, we used a 0.5-kb fragment of the 5'-flanking region of the akr1b7 gene to drive Cre expression in adrenocortica...

journal_title：Molecular and cellular endocrinology

authors： Lambert-Langlais S,Val P,Guyot S,Ragazzon B,Sahut-Barnola I,De Haze A,Lefrançois-Martinez AM,Martinez A

更新日期：2009-03-05 00:00:00

abstract：:Steroidogenic factor 1 (SF-1) is a nuclear receptor that plays important roles in the hypothalamus-pituitary-steroidogenic organ axis. Global knockout studies in mice revealed the essential in vivo roles of SF-1 in the ventromedial hypothalamic (VMH) nucleus, adrenal glands, and gonads. One limitation of global SF-1 k...

journal_title：Molecular and cellular endocrinology

authors： Kim KW,Zhao L,Parker KL

更新日期：2009-03-05 00:00:00

abstract：:Adenomas and nodules of the human adrenal cortex are common, whereas adrenocortical carcinomas are rare. Genes such as IGF2 have been suggested to be important in human adrenocortical tumorigenesis but their role has not been directly investigated. We describe here elements of a system in which hypotheses concerning t...

journal_title：Molecular and cellular endocrinology

authors： Cardoso CC,Bornstein SR,Hornsby PJ

更新日期：2009-03-05 00:00:00

abstract：:Activity of the hypothalamo-pituitary-adrenal (HPA) axis is regulated by a negative feedback loop that dampens central drive of the axis via the actions of the secreted glucocorticoids. Conversely, under conditions of chronic stress, glucocorticoids delivered centrally increase hypothalamic paraventricular nucleus (PV...

journal_title：Molecular and cellular endocrinology

authors： Warne JP

更新日期：2009-03-05 00:00:00

abstract：:The template for our understanding of the physiological role of the adrenal cortex was set by Hans Selye, who demonstrated its key involvement in the response to stress, of whatever origin, and who also introduced the terms glucocorticoid and mineralocorticoid. Despite this, from the late 1940s on there was certainly ...

journal_title：Molecular and cellular endocrinology

authors： Vinson GP

更新日期：2009-03-05 00:00:00

abstract：:The major source for dehydroepiandrosterone (DHEA) and its sulphate compound DHEA-S is the inner zone of the adrenal cortex, which is in direct contact to adrenomedullary chromaffin cells. Due to their close proximity, direct interactions of DHEA and DHEA-S with chromaffin cells during adrenal gland development and th...

journal_title：Molecular and cellular endocrinology

authors： Krug AW,Langbein H,Ziegler CG,Bornstein SR,Eisenhofer G,Ehrhart-Bornstein M

更新日期：2009-03-05 00:00:00

abstract：:Mutations of SRY are the cause of 46,XY complete pure gonadal dysgenesis (PGD) in 10-15% of patients. In this study, DNA was isolated and sequenced from blood leukocytes and from paraffin-embedded gonadal tissue in five patients with 46,XY complete PGD. DNA binding capability was analyzed by three different methods. T...

journal_title：Molecular and cellular endocrinology

authors： Sánchez-Moreno I,Canto P,Munguía P,de León MB,Cisneros B,Vilchis F,Reyes E,Méndez JP

更新日期：2009-02-27 00:00:00

abstract：:Sox genes participate in several developmental processes, including sex determination and differentiation. In this study, the genomic structure of sox17 was characterized in the sea bass (sb). Two transcripts, one producing a normal protein (sb Sox17) and another producing a truncated protein (sb t-Sox17) were detecte...

journal_title：Molecular and cellular endocrinology

authors： Navarro-Martín L,Galay-Burgos M,Sweeney G,Piferrer F

更新日期：2009-02-27 00:00:00

abstract：:The Klotho gene encodes a single-pass transmembrane protein and functions as an aging-suppressor gene, which extends lifespan when overexpressed and accelerates the development of aging-like phenotypes when disrupted in mice. Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates phosphate and vi...

journal_title：Molecular and cellular endocrinology

authors： Kurosu H,Kuro-O M

更新日期：2009-02-05 00:00:00

abstract：:Regulation of hormonal, insulin/IGF-1 (Ins/IGF-1) signaling activities, and pathways of the intrinsic generation of reactive oxygen species (ROS) play a role in aging and longevity determination. In this review we discuss the cross-talk between these pathways as mechanisms of signaling that may be important factors in...

journal_title：Molecular and cellular endocrinology

authors： Papaconstantinou J

更新日期：2009-02-05 00:00:00

abstract：:Emerging evidence shows a beneficial effect of estrogens for Parkinson's disease, yet the exact potency of these compounds implicated remain obscured. In this study, we investigated the neuroprotective effect of 17beta-estradiol and estrone against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal t...

journal_title：Molecular and cellular endocrinology

authors： Ookubo M,Yokoyama H,Takagi S,Kato H,Araki T

更新日期：2008-12-16 00:00:00

abstract：:The role of the carboxyl terminal F-domain of estrogen receptor (ERalpha) is uncertain, but evidence suggests that this region may impart internal restraint on ER dimerization in the presence of 17beta-estradiol (E2). To identify the C-terminal residues affecting human ERalpha activation, we created a series of deleti...

journal_title：Molecular and cellular endocrinology

authors： Yang J,Singleton DW,Shaughnessy EA,Khan SA

更新日期：2008-11-25 00:00:00

abstract：:The present work describes the identification of (anti)progestin endocrine disrupting chemicals (EDC) using a two step screening system. In the first step a competitive binding assay was developed using recombinant human progesterone receptor (hPR). The tested chemicals were of various classes like insecticides, their...

journal_title：Molecular and cellular endocrinology

authors： Viswanath G,Halder S,Divya G,Majumder CB,Roy P

更新日期：2008-11-25 00:00:00

abstract：:Transthyretin (TTR) transports thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3) in the blood of vertebrates. TH-binding sites are highly conserved in vertebrate TTR, however, piscine TTR has a longer N-terminus which is thought to influence TH-binding affinity and may influence TTR stability. We produc...

journal_title：Molecular and cellular endocrinology

authors： Morgado I,Melo EP,Lundberg E,Estrela NL,Sauer-Eriksson AE,Power DM

更新日期：2008-11-25 00:00:00

abstract：:The inhibins are secreted alpha:beta heterodimers of the TGF-beta superfamily that are mainly synthesized in Sertoli cells and granulosa cells, and are critical regulators of testicular and ovarian development and function. Mice homozygous for a targeted deletion of the inhibin alpha subunit gene (Inha(-/-)) develop s...

journal_title：Molecular and cellular endocrinology

authors： Nagaraja AK,Agno JE,Kumar TR,Matzuk MM

更新日期：2008-11-06 00:00:00

abstract：:Marsupials are a group of mammals that are under-exploited, in particular in developmental and evolutionary studies of biological systems. In this review, the roles that marsupials have played in elucidating the evolution of thyroid hormone distribution systems are summarised. Marsupials are born at very early develop...

journal_title：Molecular and cellular endocrinology

authors： Richardson SJ

更新日期：2008-10-10 00:00:00

abstract：:The aim of our study was to investigate the direct effects of atypical antipsychotics on muscle cell functions in order to ascertain the diabetic liability of these drugs. We investigated the effects of olanzapine, clozapine and alpha-methyl-5-hydroxytryptamine on basal glucose uptake and glucose uptake in response to...

journal_title：Molecular and cellular endocrinology

authors： Tulipano G,Spano P,Cocchi D

更新日期：2008-09-24 00:00:00

abstract：:Increased production of inflammatory cytokines is suggested to be of importance for initiation and progression of insulin resistance. Chronic treatment with the AMP analogue 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside (AICAR) has been shown to improve insulin sensitivity and prevent the development of diabe...

journal_title：Molecular and cellular endocrinology

authors： Lihn AS,Pedersen SB,Lund S,Richelsen B

更新日期：2008-09-24 00:00:00

abstract：:We find that completion of the first meiotic division in Rana pipiens oocytes requires the sequential action of at least two steroids: progesterone and one or more subsequent polar metabolites of progesterone. Progesterone binding in vitro to oocyte surface receptors increases during the first 4-5h of exposure, follow...

journal_title：Molecular and cellular endocrinology

authors： Kostellow AB,Morrill GA

更新日期：2008-09-10 00:00:00

abstract：:Best described outside the nervous system, caveolins are structural proteins that form caveolae, functional microdomains at the plasma membrane that cluster related signaling molecules. Caveolin-associated proteins include G protein-coupled receptors and G proteins, receptor tyrosine kinases, as well as protein kinase...

journal_title：Molecular and cellular endocrinology

authors： Luoma JI,Boulware MI,Mermelstein PG

更新日期：2008-08-13 00:00:00

abstract：:Estrogen receptor alpha (ERalpha) mediates estrogen (E2) actions in the brain and is critical for normal reproductive function and behavior. In the classical pathway, ERalpha binds to estrogen response elements (EREs) to regulate gene transcription. ERalpha can also participate in several non-classical pathways, inclu...

journal_title：Molecular and cellular endocrinology

authors： McDevitt MA,Glidewell-Kenney C,Jimenez MA,Ahearn PC,Weiss J,Jameson JL,Levine JE

更新日期：2008-08-13 00:00:00

abstract：:B cell-specific Moloney murine leukaemia virus integration site 1 (Bmi1), known as the first functional member of PcG (Polycomb Group) family, is supposed to be a key regulator of stem cell self-proliferation. In this study, we investigated its expression in testis and its impact on spermatogonia proliferation for bet...

journal_title：Molecular and cellular endocrinology

authors： Zhang S,Li D,Li E,Li L,Wang J,Wang C,Lu J,Zhang X

更新日期：2008-06-11 00:00:00

abstract：:Thyroid hormone (TH) has a remarkable range of actions in the development and function of the nervous system. A multigenic picture is emerging of the mechanisms that specify these diverse functions in target tissues. Distinct responses are mediated by alpha and beta isoforms of TH receptor which act as ligand-regulate...

journal_title：Molecular and cellular endocrinology

authors： Nunez J,Celi FS,Ng L,Forrest D

更新日期：2008-06-11 00:00:00

abstract：:Dopamine and somatostatin are both involved in the negative control of normal pituitary cells. Dopamine subtype 2 receptor (D2DR) and somatostatin receptor (sst) agonists, mainly directed to sst2, are used in the treatment of pituitary adenomas. Nevertheless, a majority of corticotroph and gonadotroph adenomas and a t...

journal_title：Molecular and cellular endocrinology

authors： Saveanu A,Jaquet P,Brue T,Barlier A

更新日期：2008-05-14 00:00:00

abstract：:In the retina, peptidergic signalling participates in multiple circuits of visual information processing. The neuropeptide somatostatin (SRIF) is localised to amacrine cells and, in some instances, in a subset of ganglion cells. The variegated expression patterns of SRIF receptors (sst(1)-sst(5)) and the variety of si...

journal_title：Molecular and cellular endocrinology

authors： Cervia D,Casini G,Bagnoli P

更新日期：2008-05-14 00:00:00

abstract：:Somatostatin has been discovered as a somatotroph release inhibitory factor (SRIF), and, indeed, it has been demonstrated that SRIF and its analogs can inhibit pituitary tumor hormone secretion and control neoplastic bulk. Several in vitro studies have contributed to the current knowledge of the mechanisms by which SR...

journal_title：Molecular and cellular endocrinology

authors： Zatelli MC,Ambrosio MR,Bondanelli M,degli Uberti EC

更新日期：2008-05-14 00:00:00

abstract：:Somatostatin (SST) regulates multiple biological processes via five genetically distinct, G-protein coupled receptors. Clinical interest in therapy for neuroendocrine and metabolic disorders has resulted in the development of new tools for exploring the function of somatostatin receptors (SSTRs). The development of hi...

journal_title：Molecular and cellular endocrinology

authors： Strowski MZ,Blake AD

更新日期：2008-05-14 00:00:00

abstract：:The study of the somatostatins (SS) signaling system in fish has provided important information about the structure, function, and evolution of SSs and their receptors. The SS signaling system elicits widespread biological actions via multiple hormone variants, numerous receptor subtypes, and a variety of signal trans...

journal_title：Molecular and cellular endocrinology

authors： Klein SE,Sheridan MA

更新日期：2008-05-14 00:00:00

abstract：:Somatostatin (SS) and its synthetic analogs have a role in the treatment of neuroendocrine tumours both in terms of symptoms control and antiproliferative activities. These effects are mediated by five SS receptors, widely expressed in both human neuroendocrine and non-neuroendocrine tumours, which were demonstrated t...

journal_title：Molecular and cellular endocrinology

authors： Volante M,Rosas R,Allìa E,Granata R,Baragli A,Muccioli G,Papotti M

更新日期：2008-05-14 00:00:00

abstract：:Cannabinoids, the main active components of marijuana, have been shown to exert different adverse effects on male reproduction both in vertebrates and invertebrates. The main effects of endocannabinoids, a particular group of endogenously produced cannabinoids, in sperm are the inhibition of motility, capacitation and...

journal_title：Molecular and cellular endocrinology

authors： Rossato M

更新日期：2008-04-16 00:00:00

abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine involved in autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease. IL-6 is produced by infiltrating immune cells and by thyrocytes. In the latter cell type, secretion of IL-6 is stimulated notably by interleukin-1 (IL-1), thyroid-stimulating ...

journal_title：Molecular and cellular endocrinology

authors： Szabo-Fresnais N,Blondeau JP,Pomérance M

更新日期：2008-03-12 00:00:00

abstract：:Set/template-activating factor (TAF)-Ibeta, part of the Set-Can oncogene product found in acute undifferentiated leukemia, is a component of the inhibitor of acetyltransferases (INHAT) complex. Set/TAF-Ibeta interacted with the DNA-binding domain of the glucocorticoid receptor (GR) in yeast two-hybrid screening, and r...

journal_title：Molecular and cellular endocrinology

authors： Ichijo T,Chrousos GP,Kino T

更新日期：2008-02-13 00:00:00

abstract：:Auto-regulation of the three goldfish estrogen receptor (ER) subtypes was examined simultaneously in multiple tissues, in relation to mRNA levels of liver vitellogenin (VTG) and brain transcripts. Male goldfish were implanted with a silastic implant containing either no steroid or 17beta-estradiol (E2) (100 microg/g b...

journal_title：Molecular and cellular endocrinology

authors： Marlatt VL,Martyniuk CJ,Zhang D,Xiong H,Watt J,Xia X,Moon T,Trudeau VL

更新日期：2008-02-13 00:00:00

abstract：:Elaboration of a multicellular organism requires highly efficient coordination between proliferation and developmental processes. Accordingly, the embryonic cell cycle exhibits a high degree of plasticity; however, the mechanisms underlying its regulation in vivo remain largely unknown. The purpose of this review is t...

journal_title：Molecular and cellular endocrinology

authors： Artus J,Cohen-Tannoudji M

更新日期：2008-01-30 00:00:00

abstract：:We have shown that somatostatin agonist peptide CH275, selective to somatostatin receptor (sst) subtypes 1,4, was more effective in preventing intimal hyperplasia than the sst2,3,5-selective octreotide, raising the question what are the separate roles of the sst1- and 4-subtypes. Here, we dissect this observation furt...

journal_title：Molecular and cellular endocrinology

authors： Tigerstedt NM,Aavik E,Aavik S,Savolainen-Peltonen H,Hayry P

更新日期：2007-12-15 00:00:00

abstract：:In the marmoset monkey, the LHR type II, lacking exon 10, is the native receptor type. We characterised the LHR splicing pattern in marmoset testes and the adrenals during puberty and in pre- and postpubertal ovaries and quantified mRNA LHR expression in the testis. We detected 11 LHR splicing variants expressed at si...

journal_title：Molecular and cellular endocrinology

authors： Michel C,Gromoll J,Chandolia R,Luetjens CM,Wistuba J,Simoni M

更新日期：2007-12-15 00:00:00

abstract：:Under physiological conditions substantial amounts of hormone may be degraded within endocrine cells by a crinophagic process comprising fusions of secretory granules with lysosomes. Glucocorticoids may stabilise and progesterone destabilise lysosomal membranes. The effects of corticosterone and progesterone on intrac...

journal_title：Molecular and cellular endocrinology

authors： Sandberg M,Borg LA

更新日期：2007-10-15 00:00:00

abstract：:Calbindin-D9k (CaBP-9k) is a high affinity calcium binding protein that is highly expressed in the duodenum, kidney, uterus, and pituitary glands. Previous studies have shown that CaBP-9k expression is regulated by several steroid hormones, such as 1,25-dihydroxyvitamin D3, glucocorticoids, 17beta-estradiol (E2), and ...

journal_title：Molecular and cellular endocrinology

authors： Lee GS,Choi KC,Han HJ,Jeung EB

更新日期：2007-10-15 00:00:00

abstract：:Proliferation of breast cancer cells is mediated by estrogen receptors (ER)-ERalpha and ERbeta. At present, contradictory observations complicate the understanding of involvement of ERbeta in breast cancer and functional definition of ERbeta as a prognostic marker. A stable expression of full length ERbeta was establi...

journal_title：Molecular and cellular endocrinology

authors： Behrens D,Gill JH,Fichtner I

更新日期：2007-08-15 00:00:00